I have no idea. How long did you wait to apply primer/paint over Mr. Surfacer?
I am in no way a professional painter. When I was looking to start airbrushing, I asked my painter buddy about different paints. He told me to pick one "system" and learn it: acrylic, enamel or lacquer. He advised against mixing different manufacturer's products for compatibility reasons. I chose Createx after some research due to their technical data sheet availability. Plus, they have a rather large array of colors. Easy to use and easy to clean up. The next piece of advice he gave me was PRACTICE PRACTICE PRACTICE PRACTICE AND PRACTICE MORE!