Fact-checking humor 101
1)
1) Buffalo can't talk, nor do they go to college. Therefore this isn't funny.
2)
2) Medusa didn't actually have snakes growing out of her head, and is a mythical made-up person anyway. Nor is there any historical evidence that St. Patrick actually drove the snakes out of Ireland. Furthermore, St. Patrick and Medusa are from widely separated times in history, and could not possibly have dated. Therefore this is not funny either.