I think the biggest problem with these catalyzed paints is that too many model builders use them too casually. Sure, there are those that take the proper precautions, but really taking the proper precautions is a big deal and involves quite a bit of effort and equipment.
"Hobby" paints, or even automotive paints like DupliColor, are sold primarily for use by amateurs, not professional painters. Sure they're still toxic to some extent, but a whiff of Testors or Tamiya every so often will probably not cause anyone any serious harm. You don't want to make a habit of sniffing fumes, you still want to paint either in a ventilated booth or outdoors... but odds are you're not risking your life using "hobby" paints. Two-part paints, on the other hand, are not meant to be used casually... they are meant to be used by professional painters who have the proper professional equipment needed to safely use them.
I don't think my health is worth risking for the sake of a model car. I'll leave the professional paint to the professional painters.