Yeah, I've seen quite a few wide open spaces....I've driven across the void from Reno to SLC to Cheyenne before, I-40 from Flagstaff AZ to Albuquerque and vice versa many times (when driving between Phoenix and Denver), I-80 across Nebraska, Phoenix to LA on I-10, Phoenix to San Diego via Yuma and I-8, etc..
Vast empty areas where cruise control is good to have, never let the gas tank go below half a tank, have plenty of coffee or Red Bull, and often not have a cell phone signal...